Aldol Chemistry

[352] Enantioselective Construction of Quaternary Stereogenic Carbon Atoms by the Lewis Base Catalyzed Additions of Silyl Ketene Imines to Aldehydes (with T. W. Wilson and M. T. Burk) Chem. Eur. J. 2014, 20, 9268-9279.

[342] Lewis Base Catalysis of the Mukaiyama Directed Aldol Reaction: 40 Years of Inspiration and Advances (with G. L. Beutner) Angew. Chem. Int. Ed. 2013, 52, 9086-9096.

[337] Silyl Ketene Imines: Highly Versatile Nucleophiles for Catalytic, Asymmetric Synthesis (with T. W. Wilson) Angew. Chem. Int. Ed. 2012, 51, 9980-9992.

[334] Lewis Base Catalyzed Enantioselective Additions of an N-Silyl Vinylketene Imine (with T. W. Wilson) Angew. Chem. Int. Ed. 2012, 51, 3236-3239.

[321] N-Silyl Oxyketene Imines are Underused Yet Highly Versatile Reagents for Catalytic Asymmetric Synthesis (with T. W. Wilson) Nature Chemistry 2010, 2, 937-943.

[316] Construction of Quaternary Stereogenic Carbon Centers by the Lewis Base Catalyzed Conjugate Addition of Silyl Ketene Imines to α,β-Unsaturated Aldehydes and Ketones (with T. W. Wilson) Synlett 2010, 1723-1728.

[307] On the Mechanism of Lewis Base Catalyzed Aldol Addition Reactions: Kinetic and Spectroscopic Investigations Using Rapid-Injection NMR (with B. M. Eklov, P. J. Yao, and M. D. Eastgate) J. Am. Chem. Soc. 2009, 131, 11770-11787.

[293] Lewis Base Activation of Lewis Acids: Catalytic, Enantioselective Addition of Glycolate-Derived Silyl Ketene Acetals to Aldehydes (with W. Chung) J. Org. Chem. 2008, 73, 4582-4595.

[291] Methyl Trichlorosilyl Ketene Acetal (with Y. Fan) e-EROS Encyclopedia of Reagents for Organic Synthesis [Online] 2008.

[286] Lewis Base Activation of Lewis Acids: Catalytic Enantioselective Glycolate Aldol Reactions (with Won-jin Chung) Angew. Chem. Int. Ed. 2008, 47, 1890-1892.

[283] Investigations into Transition-State Geometry in the Mukaiyama Directed Aldol Reaction ( with W. Lee) Chem. Asian J. 2008, 327-341.

[280] Enantioselective Construction of Quaternary Stereogenic Carbons by the Lewis Base Catalyzed Additions of Silyl Ketene Imines to Aldehydes (with T. W. Wilson, M. T. Burk, and J. R. Heemstra, Jr.) J. Am. Chem. Soc. 2007, 129, 14864-14865.

[275] Lewis Base Activation of Lewis Acids: Catalytic, Enantioselective Vinylogous Aldol Addition Reactions (with J. R. Heemstra) J. Org. Chem. 2007, 72, 5668-5688.

[274] Unexpected Ambidoselectivity in Crossed-Aldol Reaction of a-Oxy Aldehyde Trichlorosilyl Enolates (with S. K. Ghosh) Tetrahedron Prize Special Issue 2007, 63, 8636-8644.

[260] Chiral Phosphoramide-Catalyzed Aldol Additions of Ketone Trichlorosilyl Enolates. Mechanistic Aspects (with S. M. Pham, R. A. Stavenger, X. Su, K.-T. Wong, and Y. Nishigaichi) J. Org. Chem. 2006, 71, 3904-3922.

[254] Lewis Base Activation of Lewis Acids. Vinylogous Aldol Addition Reactions of Conjugated N,O­-Silyl Ketene Acetals to Aldehydes (with J. R. Heemstra, Jr.) J. Am. Chem. Soc. 2006, 128, 1038-1039.

[250] Lewis Base Catalyzed Aldol Additions of Chiral Trichlorosilyl Enolates and Silyl Enol Ethers (with J. Fujimori and S. M. Pham) J. Org. Chem. 2005, 70, 10823-10840.

[249] Mechanistic Insights into the Chiral Phosphoramide-Catalyzed, Enantioselective Crossed-Aldol Reactions of Aldehydes (with T. Bui) J. Org. Chem. 2005, 70, 10393-10397.

[247] Lewis Base-Catalyzed Enantioselective Aldol Addition of Acetaldehyde-Derived Silyl Enol Ether to Aldehydes (with T. Bui) J. Org. Chem. 2005, 70, 10190-10193.

[246] Catalytic, Enantioselective alpha-Additions of Isocyanides: Lewis-Base-Catalyzed Passerini-Type Reactions (with Y. Fan) J. Org. Chem. 2005, 70, 9667-9676.

[245] Catalytic, Enantioselective, Vinylogous Aldol Reactions (with J. R. Heemstra, Jr. and G. L. Beutner) Angew. Chem. Int. Ed. 2005, 44, 4682-4698.

[244] Total Synthesis of RK-397 (with S. Fujimori) J. Am. Chem. Soc. 2005, 127, 8971-8973.

[243] Lewis Base Catalyzed, Enantioselective Aldol Addition of Methyl Trichlorosilyl Ketene Acetal to Ketones (with Y. Fan and M. D. Eastgate) J. Org. Chem. 2005, 70, 5235-5248.

[239] Lewis Base Activiation of Lewis Acids: Catalytic, Enantioselective Addition of Silyl Ketene Acetals to Aldehydes (with G. L. Beutner, T. Wynn, and M. D. Eastgate) J. AM. Chem. Soc. 2005, 127, 3774-3789.

[235] Lewis Base Activation of Lewis Acids: Vinylogous Aldol Additions of Dienol Ethers to Aldehydes (with J. R. Heemstra Jr.) Synlett 2004, 13, 2411-2416.

[231] [4S-(4a,5b)]- 1 -(1,3-Dimethyl- 2 -oxido – 4,5-diphenyl-1,3,2 – diazaphospholidine- 2 -yl)piperidine (with S. M. Pham) e-EROS Encyolopedia of Reagents for Organic Synthesis [Online] 2002.

[227] Chiral Phosphoramide-Catalyzed, Enantioselective, Directed Cross-Aldol Reactions of Aldehydes (with T. Bui) Proc. Nat. Acad. Sci. 2004, 101, 5439-5444.

[219] The First Catalytic, Asymmetric alpha -Additions of Isocyanides. Lewis-Base-Catalyzed, Enantioselective Passerini-Type Reactions (with Y. Fan) J. Am. Chem. Soc. 2003, 125, 7825-7827.

[218] Lewis Base Activation of Lewis Acids. Vinylogous Aldol Reactions (with G. L. Beutner) J. Am. Chem. Soc. 2003, 125, 7800-7801.

[216] Stereoselective Aldol Additions of Achiral Ethyl Ketone-Derived Trichlorosilyl Enolates (with S. M. Pham) J. Org. Chem. 2003, 68, 5045-5055.

[215] Lewis Base Activation of Lewis Acids. Catalytic Enantioselective Addition of Silyl Enol Ethers of Achiral Methyl Ketones to Adehydes (with Jr. Heemstra Jr.) Org. Lett. 2003. 5, 2303-2306.

[205] Lewis Base Activation of Lewis Acids. Addition of Silyl Ketene Acetals to Aldehydes (with T. Wynn and G. L. Beutner) J. Am. Chem. Soc. 2002, 124, 13405-13407.

[201] The Effects of a Remote Stereogenic Center in the Lewis Base Catalyzed Aldol Additions of Chiral Trichlorosilyl Enolates (with S. Fujimori) Org. Lett. 2002, 4, 3477-3480.

[200] Diastereoselective Aldol Additions of Chiral beta -Hydroxy Ethyl Ketone Enolates Catalyzed by Lewis Bases (with S. Fujimori) Org. Lett. 2002, 4, 3473-3476.

[196] Catalytic, Enantioselective Aldol Additions to Ketones (with Y. Fan) J. Am. Chem. Soc. 2002, 124, 4233-4235.

[192] The First Catalytic, Diastereoselective, and Enantioselective Crossed-Aldol Reactions of Aldehydes (with S. K. Ghosh) Angew. Chem. Int. Ed. 2001, 40, 4759-4762.

[189] Highly Diastereoselective Aldol Additions of a Chiral Ethyl Ketone Enolate Under Lewis Base Catalysis (with S. M. Pham) Org. Lett. 2001, 3, 2201-2204.

[188] Diastereoselective Aldol Addition Reactions of a Chiral Methyl Ketone Trichlorosilyl Enolate under Lewis Base Catalysis (with S. Fujimori) Synlett 2001, SI, 1024-1029.

[177] The Chemistry of Trichlorosilyl Enolates. Aldol Addition Reactions of Methyl Ketones (with R. A. Stavenger) J. Am. Chem. Soc. 2000, 122, 8837-8847.

[175] Kinetic Analysis of the Divergence of Reaction Pathways in the Chiral Lewis Base Promoted Aldol Addition of Trichlorosilyl Enolates: A Rapid Injection NMR Study (with S. M. Pham) Helv. Chim. Acta 2000, 83, 1846-1853.

[171] Asymmetric Catalysis of Aldol Reactions with Chiral Lewis Bases (with R. A. Stavenger) Accounts Chem. Res. 2000, 33, 432-440.

[164] Solid State and Solution Structural Studies of Chiral Phosphoramide-Tin Complexes Relevant to Lewis Base Catalyzed Aldol Addition Reactions (with X. Su) Tetrahedron 1999, 55, 8727-8738.

[162] Chiral Phosphoramide-Catalyzed Aldol Additions of Ketone Enolates. Preparative Aspects (with R. A. Stavenger, K.-T. Wong and X. Su) J. Am. Chem. Soc. 1999, 121, 4982-4991.

[157] The Chemistry of Trichlorosilyl Enolates. 6. Mechanistic Duality in the Lewis Base-Catalyzed Aldol Addition Reaction (with X. Su and Y. Nishigaichi) J. Am. Chem.Soc. 1998, 120, 12990-12991.

[156] Highly 1,4-syn Diastereoselective, Phosphoramide-Catalyzed Aldol Additions of Chiral Methyl Ketone Enolates (with R. A. Stavenger) J. Org. Chem. 1998, 63, 9524-9527.

[155] Preparation of Chlorosilyl Enolates (with R. A. Stavenger, S. B. D. Winter, K.-T. Wong and P. A. Barsanti) J. Org. Chem. 1998, 63, 9517-9523.

[154] Asymmetric Catalysis with Chiral Lewis Bases (with R. A. Stavenger, X. Su, K.-T. Wong and Y. Nishigaichi) Pure Appl. Chem. 1998, 70, 1469-1476.

[151] Asymmetric Aldol Additions Catalyzed by Chiral Phosphoramides: Electronic Effects of the Aldehyde Component (with R. A. Stavenger and K.-T. Wong) Tetrahedron 1998, 54, 10389-10402.

[143] Lewis Base-Catalyzed, Asymmetric Aldol Additions of Methyl Ketone Enolates (with R. A. Stavenger and K.-T. Wong) J. Org. Chem. 1998, 63, 918-919.

[139] The Chemistry of Chlorosilyl Enolates. 3. Variation of the Silyl Group and the Effect on Rate and Enantiomeric Excess of Acetate Aldol Additions (with S. B. D. Winter) Synlett 1997, 1087-1089.

[132] The Chemistry of Trichlorosilyl Enolates. 2. Highly-Selective Asymmetric Aldol Additions of Ketone Enolates (with K.-T. Wong and R. A. Stavenger) J. Am. Chem. Soc. 1997, 119, 2333-2334.

[120] The Chemistry of Trichlorosilyl Enolates. 1. New Reagents for Catalytic Asymmetric Aldol Additions (with S. B. D. Winter, X. Su and K.-T. Wong) J. Am. Chem. Soc. 1996, 118, 7404-7405.

[97] The Chemistry of Enoxysilacyclobutanes. 3. Uncatalyzed, Syn-Selective, Asymmetric Aldol Additions (with B. D. Griedel) J. Org. Chem. 1994, 59, 5136-5138.

[93] The Chemistry of Enoxysilacyclobutanes: Highly Selective Uncatalyzed Aldol Additions (with B. D. Griedel, D. M. Coe and M. E. Schnute) J. Am. Chem. Soc. 1994, 116, 7026-7043.

[92] Triarylcarbenium Ions as Catalysts in the Mukaiyama Aldol Addition: A Mechanistic Investigation (with C.-T. Chen) Tetrahedron Lett. 1994, 35, 4327-4330.

[89] Investigations on Transition-State Geometry in the Lewis Acid- (Mukaiyama) and Fluoride-Promoted Aldol Reaction (with W. Lee) J. Org. Chem. 1994, 59, 707-709.

[79] The Chemistry of Enoxysilacyclobutanes: Highly Selective, Uncatalyzed Aldol Additions (with B. D. Griedel and D. M. Coe) J. Org. Chem. 1993, 58, 988-990.

[75] Investigations on Transition State Geometry in the Aldol Condensation in Aqueous Medium (with W. Lee) Tetrahedron Lett. 1992, 33, 7729-7732.

[59] Investigations on Transition State Geometry in the Aldol Condensation (with B. R. Henke) J. Am. Chem. Soc. 1991, 113, 2177-2194.

[41] Investigations on Transition State Geometry in the Aldol Condensation (with B. R. Henke) J. Am. Chem. Soc. 1989, 111, 8032-8034.